Sweet syndrome

• related: Dermatology

• aka acute febrile neutrophilic dermatosis
• pathophysiology: after URI or GI infection, in setting of heme problems such as MDS or myelodysplastic syndrome evolving to AML
• association with medications that stimulates neutrophils: all-trans retinoic acid, GCS-F
• sx:
  • high fever
  • neutrophilia
  • leukocytosis with left shift
  • elevated inflammatory markers
  • muscle/joint pain
  • dense dermal infiltrate on histology
  • "juicy" skin lesions: painful, edematous, red to violet
  • no infection, responsive to steroids

mimics cellulitis